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Macrophages are innate immune cells with well-established roles in the primary response to pathogens, but also in tissue homeostasis, coordination of the adaptive immune response, inflammation, resolution, and repair. These cells recognize danger signals through receptors capable of inducing specialized activation programs. The classically known macrophage activation is induced by IFN-γ, which triggers a harsh proinflammatory response that is required to kill intracellular pathogens.doi:10.1007/springerreference_31764 fatcat:zy3yrf7rtvexplmzyqjz5a6wxm