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The effects of gold nanoparticles on Leydig cells and male reproductive function in mice
Background: Gold nanoparticles (AuNPs) have shown great promise in various biomedical applications, but their effects on male reproductive function remain to be ascertained. The aim of this study was to investigate the uptake, cytotoxicity and testosterone production inhibition of AuNPs in mouse Leydig cells, as well as their accumulation in the testes of male mice and their effects on male reproductive function.Results: AuNPs (5 nm) were able to be internalized into the endosomes/lysosomes ofdoi:10.21203/rs.3.rs-41728/v1 fatcat:dhgllmgvtfgcng27ckmf4uylra