Influences of prenatal nicotine exposure on behavioral functions of the offspring: Involvement of chemokine levels in the brain

Ryoko Kimata, Takayoshi Mamiya, Riho Takekawa, Ai Ito, Daisuke Ibi, Toshitaka Nabeshima, Masayuki Hiramatsu
2019 Proceedings for Annual Meeting of The Japanese Pharmacological Society  
The cigarette smoking during pregnancy is thought to induce the dysfunction of emotional and cognitive function of offspring. In our previous studies, we have reported that prenatal nicotine exposure affects the proliferation and maturation of progenitor cells to glutamatergic and dopaminergic neurons during neurodevelopment in the medial PFC, which may be associated with behavioral impairments in the offspring. Recently, there is a hypothesis that inflammation during pregnancy might impair
more » ... cy might impair brain function of offspring. Here, we investigated whether prenatal nicotine exposure might affect the expression of chemokines in mice. Pregnant mice were exposed to nicotine solution (0.2 mg/mL) dissolved in 2 % saccharin by drinking till embryonic day 14 (E14) to birth (P0) of offspring. On E15, 16, 18 and P1, we examined the protein levels of 10 chemokines in the brain. The prenatal nicotine exposure increased the expression levels of CXCL1 and CCL2, but decreased those of CCL3, CCL4, CCL11 and CCL5 compared to those in the control on P1. It is suggested that prenatal nicotine exposure may influence the chemokine balance in the brain of offspring. Poster Sessions
doi:10.1254/jpssuppl.92.0_3-p-048 fatcat:rjrpvgoytvffla5bkouwonhtum