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The promise of "personalized medicine" guided by an understanding of each individual's genome has been fostered by increasingly powerful and economical methods to acquire clinically relevant information. We describe the operational implementation of prospective genotyping linked to an advanced clinical decision-support system to guide individualized health care in a large academic health center. This approach to personalized medicine entails engagement between patient and health-care provider,doi:10.1038/clpt.2011.371 pmid:22588608 pmcid:PMC3581305 fatcat:55m2w7vb2rdmpdkgf6tauv3d6a