Multilocus Sequence Types and Virulence Determinants of Hypermucoviscosity-Positive Klebsiella pneumoniae Isolated from Community-Acquired Infection Cases in Harbin, North China
Japanese journal of infectious diseases (Print)
We investigated the molecular epidemiologic characteristics and virulence of hypermucoviscosity-positive Klebsiella pneumoniae in mainland China. We detected 16 hypermucoviscositypositive strains in 65 total clinical isolates (24.62z). We found that 68.75z (11/16) of the positive strains had K2 genotype and carried the rmpA and iucA genes. Multilocus sequence typing revealed 5 sequence types (STs) : ST65 , ST23 , ST86 , ST412 , ST375 , whereas the remaining 4 isolates were
... as other STs. The order of the median lethal dose values for the ST types was ST23 (2.19 × 10 3 CFU/mouse) < ST86 (1.70 × 10 4 CFU/mouse) < ST65 (5.05 × 10 7 CFU/mouse) < the other STs (1.90 × 10 8 CFU/mouse). In conclusion, the K2 with ST65 carrying rmpA and iucA was the most predominant among the hypermucoviscosity-positive K. pneumoniae strains obtained from communityacquired infection cases in Harbin, North China. Sequence types are a valuable tool to predict the risk of K. pneumoniae infection.