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The effect of inactivation of calcium channels by intracellular Ca2+ ions in the bursting pancreatic β-cells
1987
Cell Biophysics
Preserved Fulltext
Based on recently determined ionic channel properties, a simple theoretical model for the burst activity of the pancreatic 6-cell is formulated in this paper. The model contains an inward voltage-activated Ca 2 + current which is inactivated by intracellular calcium ions and an outward K + current that is activated by the membrane potential. The probability of opening of the channel gates is represented by Boltzmann equations. Our model is applicable in a regime where an ATP-blockable K +
doi:10.1007/bf02797114
pmid:2450671
fatcat:ny6n3edtcndrjl7l26ni2bexu4