Comparison of Tests for Fecal Lactoferrin and Fecal Occult Blood for Colorectal Diseases. A Prospective Pilot Study

Osamu SAITOH, Keishi KOJIMA, Masanobu KAYAZAWA, Kazunori SUGI, Seigou TANAKA, Ken NAKAGAWA, Tsutomu TERANISHI, Ryoichi MATSUSE, Kazuo UCHIDA, Hiroshi MORIKAWA, Ichiro HIRATA, Ken-ichi KATSU
2000 Internal medicine (Tokyo. 1992)  
Objective This prospective pilot study was conducted to compare the usefulness of measuring fecal lactoferrin (LI) to that of fecal occult blood (FOB) test for detection of colorectal diseases. Patients and Methods The subjects were 351 patients whounderwentcolonoscopy. Afecal sample was obtained on the day before colonoscopy. Fecal Lf was measured by enzyme-linked immunosorbent assay. The FOBtest was performed by combined assay (latex agglutination) of hemoglobinand transferrin. Results The
more » ... rin. Results The specificities of the fecal Lf and FOBtests were the same (88.7 %). For patients with colorectal cancer (13), colorectal polyp (69), ulcerative colitis (18), Crohn' s disease (13), non-specific colitis (8), internal hemorrhoids (60), colon diverticulum (27) , and miscellaneous diseases of the colon (10), the rates of positivity for fecal Lf were II 13, 14/69, 12/18, 7/13, 4/8, 22/60, 8/27, and 6/10, respectively. The corresponding rates for FOB were 8/13, 12/69, ll/18, 4/13, 4/8, 9/60, 2/27, and 1/10. For patients with internal hemorrhoids, the rate of positivity for fecal Lf was significantly higher than that for FOB. In other disease groups, there was no significant difference in the rate of positivity between fecal Lf and FOB. Conclusion These findings suggest that measurement of fecal Lf is as useful as FOBin detecting colorectal diseases. (Internal Medicine 39: 778-782, 2000)
doi:10.2169/internalmedicine.39.778 fatcat:xp2kazfwvffetg2zx4evibzp3m