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Inferring gene regulatory networks by thermodynamic modeling
2008
BMC Genomics
To date, the reconstruction of gene regulatory networks from gene expression data has primarily relied on the correlation between the expression of transcription regulators and that of target genes. Results: We developed a network reconstruction method based on quantities that are closely related to the biophysical properties of TF-TF interaction, TF-DNA binding and transcriptional activation and repression. The Network-Identifier method utilized a thermodynamic model for gene regulation to
doi:10.1186/1471-2164-9-s2-s19
pmid:18831784
pmcid:PMC2559883
fatcat:gg7cpggfofbrzmlbnmm3eoor4u