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Antimycobacterial activity of synthetic pamamycins
Journal of Antimicrobial Chemotherapy
Objectives: Early studies have indicated that pamamycins, a group of macrodiolides first isolated from Streptomyces alboniger, have potent antimicrobial activity against Gram-positive bacteria, fungi and mycobacteria but not against Gram-negative bacteria. The recent availability of highly purified and reasonable quantities of several pamamycins through their total syntheses has rendered possible more extensive studies on their effects on mycobacteria. Methods: Bioluminescent strains ofdoi:10.1093/jac/dkh402 pmid:15317744 fatcat:hy5flhp6ybcvpifmhlru63x2km