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eMAFFTadd: scaling MAFFT-linsi-add to large datasets
[article]
2022
bioRxiv
pre-print
Multiple sequence alignment is essential for many biological downstream analyses. Yet, accurate alignments on large datasets are challenging and can require very long running times; since new sequence data are frequently and regularly obtained, this calls for methods that can add sequences into large alignments rather than requiring the re-estimation from scratch. In addition, sequence datasets exhibiting substantial sequence length heterogeneity are also difficult to align with high accuracy.
doi:10.1101/2022.05.23.493139
fatcat:lkwchbd4hnak7copjv3txnkyzu