Increased sister chromatid exchange frequencies in lymphocytes of nurses handling cytostatic drugs

Hannu Norppa, Marja Sorsa, Harri Vainio, Pentti Gröhn, Erkki Heinonen, Lars Holsti, Eeva Nordman
1980 Scandinavian Journal of Work, Environment and Health  
NORPPA H, SORSA M, VAINIO H, GROHN P, HEINONEN E, HOLSTI LR, NORD-MAN E. Increased sister chroma tid exchange frequencies in lymphocytes of nurses handling cytostatic drugs. Scand j w01'k envi1'on health 6 (1980) 299-301. In oncology units, personnel handling chemotherapeutic drugs may occasionally be exposed to small amounts of genotoxic agents. This exposure was obviously the cause of the increased frequencies of sister chromatid exchange (SCE) observed in nurses in daily contact with
more » ... ontact with cytostatics (N = 20, mean SCEs/cell ± SE 9.4 ± 0.3) as compared to a group of office workers (N = 10, mean SCEs/cell 8.1 ± 0.3). The oncology nurses also had a higher SCE frequency than other hospital nurses (N = 10, mean SOEs/cell 8.7 ± 0.2), but this difference was not statistically significant. The SCEs of patients under chemotherapy were about five times higher (mean SCEs/cell 36.8 ± 0.6) than those of healthy subjects.
doi:10.5271/sjweh.2605 fatcat:sjybuv2w6jfxhikf4n36g7s7mu