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Balancer chromosomes are tools used by fruit fly geneticists to prevent meiotic recombination. Recently, CRISPR/Cas9 genome editing has been shown capable of generating inversions similar to the chromosomal rearrangements present in balancer chromosomes. Extending the benefits of balancer chromosomes to other multicellular organisms could significantly accelerate biomedical and plant genetics research. Results: Here, we present GRIBCG (Guide RNA Identifier for Balancer Chromosome Generation), adoi:10.1101/484360 fatcat:mbipnyhl7rc4jpju2mld34axqa