Structure-based prediction of protein allostery

Joe G Greener, Michael JE Sternberg
2018 Current Opinion in Structural Biology  
Allostery is the functional change at one site on a protein caused by a change at a distant site. In order for the benefits of allostery to be taken advantage of, both for basic understanding of proteins and to develop new classes of drugs, the structure-based prediction of allosteric binding sites, modulators and communication pathways is necessary. Here we review the recently emerging field of allosteric prediction, focusing mainly on computational methods. We also describe the search for
more » ... tic binding pockets and attempts to design allostery into proteins. The development and adoption of such methods is essential or the long-preached potential of allostery will remain elusive.
doi:10.1016/j.sbi.2017.10.002 pmid:29080471 fatcat:lxfjcncgyza4lbwofbteux5gna