Heterologous Activation of Protein Kinase C Stimulates Phosphorylation of δ-Opioid Receptor at Serine 344, Resulting in β-Arrestin- and Clathrin-mediated Receptor Internalization

Bin Xiang, Guo-Hua Yu, Jun Guo, Li Chen, Wei Hu, Gang Pei, Lan Ma
2000 Journal of Biological Chemistry  
The purpose of the current study is to investigate the effect of opioid-independent, heterologous activation of protein kinase C (PKC) on the responsiveness of opioid receptor and the underlying molecular mechanisms. Our result showed that removing the C terminus of ␦ opioid receptor (DOR) containing six Ser/Thr residues abolished both DPDPE-and phorbol 12-myristate 13acetate (PMA)-induced DOR phosphorylation.
doi:10.1074/jbc.m006187200 pmid:11085981 fatcat:l7pc35txtrdyfjb2aeajbvrdyi