Comparison of Efficacy of Difluprednate Emulsion vs Topical Prednisolone Acetate on Post Phacoemulsification Inflammation
International Journal of Contemporary Medical Research [IJCMR]
Phacosmulsification with IOL implantation is currently the procedure of choice for cataract surgery as it offers the best visual results. Two main groups of drugs used to control postoperative inflammation following cataract surgery are NSAIDS, which directly inhibit the cox enzymes and topical corticosteroids, which act at the level of phospholipase A2. Study objective was to compare the efficacy of 0.05% difluprednate emulsion and 1% prednisolone acetate suspension on post phaco inflammation.
... phaco inflammation. Material and methods: 80 patients undergoing phacoemulsification in tertiary health care centre were randomly divided into 2 groups. Postoperatively, patients in group A were put on 0.05% difluprednate eye drops while group B were put on 1%prednisolone acetate eye drops for 42 days each. At each visit evaluation was done for BCVA, IOP, ocular pain grading, slit lamp for aqueous cells/ flare score. Results: At end of study, 97.5% patients in group A and 95% patients in group B had BCVA of 6/6. None of patients in any group showed significant rise in IOP >21mmHg. 95% patients in both groups showed ocular pain grade of 1 while 2% patients in group A and 1% in group B showed ocular pain grade of 2. 97.5%in group A and 95% in group B presented with 100% aqueous cell clearing while 97.5% patients in both groups and showed flare score 0 at last follow up. Conclusion: Topical 0.05%difluprednate ophthalmic emulsion is as effective as 1% prednisolone acetate in treating post phacoemulsification inflammation with the advantage of uniform drug dosage and no preservative.