Differential Expression and Interaction network construction of Noncoding RNA and mRNA in Heart Tissue associated with Tetralogy of Fallot [article]

Lin Liu, Hongdan Wang, Cunying Cui, Yanan Li, Yuanyuan Liu, Taibing Fan, Bangtian Peng
2020 bioRxiv   pre-print
Tetralogy of Fallot (TOF) is still the most common and complicated cyanotic congenital heart defect of all congenital heart diseases with a 10% incidence. Surgery repair is often necessary in infancy. The etiology of TOF is complex and genetic and epigenetic mechanisms such as chromosomal abnormalities, gene mutations, nucleic acid modifications, non-coding RNA, and circular RNA (circRNA) play an important role in its occurrence. RNA not only plays an auxiliary role of genetic information
more » ... c information carrier, but also plays a more important role in various regulatory functions. There are few studies on the action mechanism of non-coding RNA. Aim to gain more in-depth knowledge of TOF, we collected tissue samples of the right ventricular outflow tract of 5 TOF children with no other intracardiac and extracardiac malformations and 5 normal fetuses. We systematically analyzed the specific long non-coding RNA (lncRNA), microRNA (miRNA), circRNA and messenger RNA (mRNA) profiles of TOF. To our knowledge, there are no reports of genome-wide study of transcriptome in TOF and we first obtained meaningful differentially expressed lncRNAs, miRNAs, circle RNA and mRNAs.
doi:10.1101/2020.02.18.953877 fatcat:7mwsavpb2fbs3nrghe5vex4r5m