Thirteenth meeting of the European Neurological Society 14–18June 2003,Istanbul, Turkey

2003 Journal of Neurology  
Immediately after injury, before the glial scar has had time to form, the major impediments to regeneration in the adult CNS are inhibitors associated with myelin. To date, 3 inhibitors have been described: myelin-associated glycoprotein (MAG), Nogo and oligodendrocyte, myelin glycoprotein (OMgp). Surprisingly, all 3 of these inhibitors interact with the same receptor complex to exert their effects. The common binding partner was first identified as a receptor for the 66 extracellular amino
more » ... s of Nogo (Nog066) and was termed NgR. All 3 inhibitors bind NgR with similar mechanisms involved in the onset of migraine attacks and the interaction with migraine trigger factors. This may ultimately lead to specific, more effective and well tolerated migraine prophylactic drugs. Because of the many clinical and pathophysiological similarities, other episodic disorders such as ataxia, epilepsy, and trauma-triggered cerebral oedema may profit as well from these developments.
doi:10.1007/bf03160427 fatcat:dra3sin345hullyy7lbyrzyjsa