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Advantages of using graph databases to explore chromatin conformation capture experiments
2021
BMC Bioinformatics
High-throughput sequencing Chromosome Conformation Capture (Hi-C) allows the study of DNA interactions and 3D chromosome folding at the genome-wide scale. Usually, these data are represented as matrices describing the binary contacts among the different chromosome regions. On the other hand, a graph-based representation can be advantageous to describe the complex topology achieved by the DNA in the nucleus of eukaryotic cells. Here we discuss the use of a graph database for storing and
doi:10.1186/s12859-020-03937-0
pmid:33902433
pmcid:PMC8073886
fatcat:hmiaaz7tgza4hc74cflhovjva4