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In Vitro Electrophysiologic Effects of Morphine in Rabbit Ventricular Myocytes
2005
Anesthesiology
Morphine is widely used in patients undergoing surgical operations and is also reported to mediate cardioprotection of preconditioning. The current study determined effects of morphine at therapeutic to pharmacologic concentrations on cardiac action potential, L-type Ca 2؉ current (I Ca.L ), delayed rectifier K ؉ current (I K ), and inward rectifier K ؉ current (I K1 ) in isolated rabbit ventricular myocytes. Methods: Ventricular myocytes were enzymatically isolated from rabbit hearts. Action
doi:10.1097/00000542-200508000-00011
pmid:16052110
fatcat:pefsipggzbchdhjp6t2za2ppje