metabolic activity (p ¼ 0.002) and differentiation (p < 0.001) relative to control glass substrates at day 7. Similar results were observed on gold, and thiol surfaces were also found to initiate early neurodifferentiation in the absence of trophic factors. Conclusion: Organofunctionalisation potentially offers a simple and costeffective cross-platform technology through which the biocompatibility of neurosurgical implants could be easily improved. Our results are highly encouraging, yet it is

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... ow essential that work is repeated using a co-culture model to investigate the inflammatory component of device rejection. Aim: 778 Scots are waiting for a transplant and last year 43 died whilst waiting. Only 42% of eligible Scots are on the organ donor register (ODR). Apathy is a barrier: 32% of those unregistered said they would join, demonstrating a potential focus for a targeted marketing campaign. Methods: In 2005, the Scottish "Kill Jill" campaign focused on the contemporary trend of voting for outcome (cost: £325,000). In 2008, the "Connected" marketing had a more personal approach (cost: £615,000). Results: "Kill Jill" increased new Scottish registrations by 33%, compared to the 6.5% English increase over the same period. The 108,423 new registrations should mean six additional renal transplants over a decade. The subsequent "Connected" campaign generated 34,729 more registrations, a 1.8% growth in ODR. It was predicted that this would result in 2.6 extra transplants. Conclusion: Marketing is expensive and results are difficult to quantify. One renal transplant saves £214 000 per person compared to dialysis. If only one of 108,423 donates both kidneys after death, the "Kill Jill" campaign has paid for itself. The "Connected" campaign predicted that each £1 spent, saves the NHS £5.28. ODR campaigns deliver a healthy return-of-interest and the initial considerable outlay should result in many lives transformed and saved.