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Kir6.2, a key component of the ATP-sensitive potassium channel (K ATP ), can directly interact with imidazoline derivativesa kind of potential antidiabetic drug. This paper explores the interaction of Kir6.2 with four imidazoline derivatives by using AutoDock and Gromacs programs. The docking results reveal that the binding sites of the four imidazolines are different from each other: Idazoxan lies in a polar active pocket formed by residues H177, G299 and R301; while RX871024 is situated in adoi:10.1080/08927020903141035 fatcat:hq2sh76cmvarxjdvtu7pkjmgea