COMPARATIVE STUDY OF LIPID FRACTIONS IN TYPE- I AND TYPE- II DIABETES IN RELATION TO ITS DURATION, SEVERITY AND TYPE OF MEDICATION
International Journal of Biomedical Research
and Objective: Diabetes mellitus comprises a group of common metabolic disorder that share the phenotype of hyperglycemia. The aim of present study was to evaluate the serum lipid and lipoprotein profile in diabetes. Materials and Methods: In the present study a total of 200 patients diagnosed for diabetes mellitus (both Type-I and Type-II) were included in the study. All the participants were subjected to the procedures like a detailed history, Urine analysis, Biochemical analysis for fasting
... alysis for fasting blood sugar, Fasting Serum triglycerides, Total cholesterol, HDL, LDL and VLDL. Students't' test, one way ANOVA followed by Tukey's test was used to find out the significance of difference using SPSS version 11. P values less than 0.05 was considered the level of significance. Result: It was observed that there was an increase in the levels of Triglycerides (TG), Total cholesterol (TC), Low Density Lipoprotein-cholesterol (LDLc) and Very Low Density Lipoproteincholesterol (VLDLc) with increasing severity of diabetes. The difference in the values of these lipid fractions between Grade-I and Grade-III severity of diabetes was statistically significant (p<0.01). Even though the High Density Lipoprotein-cholesterol (HLDc) values did not show statistically significant difference between the groups, the HLDc /TC ratio was significantly reduced (p<0.01) between Grade-I and Grade-III severity of diabetes. Conclusion: Diabetes Mel1itus has real impact on lipid metabolism which was substantiated by the fact that all the lipid fractions were elevated in diabetics.