Ultrasound-assisted green synthesis of pyrroles and pyridazines in water via three-component condensation reactions of arylglyoxals

Bagher Eftekhari-Sis, Saleh Vahdati-Khajeh
2013 Current Chemistry Letters  
A green and efficient method for the preparation of 5-aryl-4-hydroxy-2-methyl-1H-pyrrole-3carboxylic acid esters and 6-aryl-3-methylpyridazine-4-carboxylic acid esters via threecomponent reaction of arylglyoxal hydrates with β-dicarbonyl compounds in the presence of ammonium acetate and hydrazine hydrate using water as solvent under ultrasonic irradiation was reported. The reactions proceeded rapidly and afforded the corresponding pyrroles and pyridazines in good to high yields in very short reaction time.
doi:10.5267/j.ccl.2013.02.002 fatcat:ma7mm6wfwjc6ne2jvk7uzjeol4