High performance computation of landscape genomic models including local indicators of spatial association

S. Stucki, P. Orozco-terWengel, B. R. Forester, S. Duruz, L. Colli, C. Masembe, R. Negrini, E. Landguth, M. R. Jones, M. W. Bruford, P. Taberlet, S. Joost
2016 Molecular Ecology Resources  
Since its introduction, landscape genomics has developed quickly with the increasing availability of both molecular and topo-climatic data. The current challenges of the field mainly involve processing large numbers of models and disentangling selection from demography. Several methods address the latter, either by estimating a neutral model from population structure or by inferring simultaneously environmental and demographic effects. Here we present Samβada, an integrated approach to study
more » ... natures of local adaptation, providing rapid processing of whole genome data and enabling assessment of spatial association using molecular markers. Specifically, candidate loci to adaptation are identified by automatically assessing genome-environment associations. In complement, measuring the Local Indicators of Spatial Association (LISA) for these candidate loci allows to detect whether similar genotypes tend to gather in space, which constitutes a useful indication of the possible kinship relationship between individuals. In this paper, we also analyze SNP data from Ugandan cattle to detect signatures of local adaptation with Samβada, BayEnv, LFMM and an outlier method (FDIST approach in Arlequin) and compare their results. Samβada is an open source software for Windows, Linux and MacOS X available at
doi:10.1111/1755-0998.12629 pmid:27801969 fatcat:aw4q5skf4rh3nejmlerrnfuhnu