Subject :Hand Osteoarthritis (HOA) is know as degenerative cartilage cell disease in joint association with generation various inflammatory responses . This disease is more common in geriatric and effected by many factors such as obesity . Leptin is hormones secreted of fatty tissue involve as mediators in many pathophysiology process , and support inflammation at cartilage of hand joint . Objective of the Study: Role of leptin concentration level in progression of hand Osteoarthritis .

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... s and Methods: This study was done on 60 patients with HOA disease and 60 healthy persons (control ), the all subjects age within this study were more than 60 years of both genders .After obtained serum , immediately used quantity method (immunoassay) for measured level of leptin concentration . Results: This study shows elevation of serum leptin concentration level in HOA group compare with healthy control group . Conclusion: This study confirms that serum leptin concentration level can act as support HOA disease progression .