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INTEGRATION OF COMPLEMENTARY BIOMARKERS IN PATIENTS WITH FIRST EPISODE PSYCHOSIS: RESEARCH PROTOCOL OF A PROSPECTIVE FOLLOW UP STUDY

Martina Rojnic Kuzman, Zagreb University Hospital Centre, Zagreb, Croatia, Porin Makaric, Dina Bosnjak Kuharic, Ivana Kekin, Linda Rossini Gajsak, Marina Boban, Nada Bozina, Tamara Bozina, Mirela Celic Ruzic, Sanja Darmopil, Igor Filipcic (+34 others)
2019 Psychiatria Danubina  

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In this project, we recruited a sample of 150 patients with first episode of psychosis with schizophrenia features (FEP) and 100 healthy controls. We assessed the differences between these two groups, as well as the changes between the acute phase of illness and subsequent remission among patients over 18-month longitudinal follow-up. The assessments were divided into four work packages (WP): WP1-psychopathological status, neurocognitive functioning and emotional recognition; WP2-stress
more » ... measured by saliva cortisol during a stress paradigm; cerebral blood perfusion in the resting state (with single photon emission computed tomography (SPECT) and during activation paradigm (with Transcranial Ultrasonography Doppler (TCD); WP3-post mortem analysis in histologically prepared human cortical tissue of post mortem samples of subjects with schizophrenia in the region that synaptic alteration was suggested by WP1 and WP2; WP4-pharmacogenetic analysis (single gene polymorphisms and genome wide association study (GWAS). We expect that the analysis of these data will identify a set of markers that differentiate healthy controls from patients with FEP, and serve as an additional diagnostic tool in the first episode of psychosis, and prediction tool which can be then used to help tailoring individualized treatment options. In this paper, we describe the project protocol including aims and methods and provide a brief description of planned post mortem studies and pharmacogenetic analysis.
doi:10.24869/psyd.2019.162 fatcat:rbdjukzavjf5rkx3szya3hjrja
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Martina Rojnic Kuzman, Zagreb University Hospital Centre, Zagreb, Croatia, Porin Makaric, Dina Bosnjak Kuharic, Ivana Kekin, Linda Rossini Gajsak, Marina Boban, Nada Bozina, Tamara Bozina, Mirela Celic Ruzic, Sanja Darmopil, Igor Filipcic, Lana Ganoci, Ana Hladnik, Zoran Madzarac, Branko Malojcic, Alma Mihaljevic Peles, Daniel J. Mueller, Drazenka Ostojic, Zdravko Petanjek, Ratimir Petrovic, Zeljka Vogrinc, Aleksandar Savic, Ante Silic, Marina Sagud, Maja Zivkovic, Zarko Bajic, University Psychiatric Hospital Vrapce, Zagreb, Croatia, Zagreb University Hospital Centre, Zagreb, Croatia, Neuropsychiatric Hospital "Dr. Ivan Barbot", Popovaca, Croatia, Zagreb University Hospital Centre, Zagreb, Croatia, Zagreb School of medicine, Zagreb, Croatia, Neuropsychiatric Hospital "Dr. Ivan Barbot", Popovaca, Croatia, Zagreb School of medicine, Zagreb, Croatia, Neuropsychiatric Hospital "Sveti Ivan", Zagreb, Croatia, Zagreb University Hospital Centre, Zagreb, Croatia, Zagreb School of medicine, Zagreb, Croatia, Zagreb University Hospital Centre, Zagreb, Croatia, Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada and Department of Psychiatry, University of Toronto, Toronto, ON, Canada, University Psychiatric Hospital Vrapce, Zagreb, Croatia, Zagreb School of medicine, Zagreb, Croatia, Zagreb University Hospital Centre, Zagreb, Croatia, University Psychiatric Hospital Vrapce, Zagreb, Croatia, Department of Psychiatry, Clinical Hospital Centre "Sestre Milosrdnice", Zagreb, Croatia, Zagreb University Hospital Centre, Zagreb, Croatia, Biometrika Healthcare Research, Zagreb, Croatia. "INTEGRATION OF COMPLEMENTARY BIOMARKERS IN PATIENTS WITH FIRST EPISODE PSYCHOSIS: RESEARCH PROTOCOL OF A PROSPECTIVE FOLLOW UP STUDY." Psychiatria Danubina 31.2 (2019) 162-171