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Role of the Second and Third Intracellular Loops of Metabotropic Glutamate Receptors in Mediating Dual Signal Transduction Activation
1998
Journal of Biological Chemistry
On the basis of sequence homology and structural similarities, metabotropic glutamate receptors (mGluRs), extracellular Ca 2؉ -sensing receptor, ␥-aminobutyric acid type B receptor, and pheromone receptors are enlisted in a distinct family within the larger G proteincoupled receptor superfamily. When expressed in heterologous systems, group I mGluRs can activate dual signal transduction pathways, phosphoinositides turnover and cAMP production. To investigate the structural basis of these
doi:10.1074/jbc.273.10.5615
pmid:9488690
fatcat:xw56exyjxjejlj7xhhzuxljgia