RNA secondary structures having a compatible sequence of certain nucleotide ratios [article]

Christopher L. Barrett and Thomas J. X. Li and Christian M. Reidys
2016 arXiv   pre-print
Given a random RNA secondary structure, S, we study RNA sequences having fixed ratios of nuclotides that are compatible with S. We perform this analysis for RNA secondary structures subject to various base pairing rules and minimum arc- and stack-length restrictions. Our main result reads as follows: in the simplex of the nucleotide ratios there exists a convex region in which, in the limit of long sequences, a random structure a.a.s. has compatible sequence with these ratios and outside of
more » ... h a.a.s. a random structure has no such compatible sequence. We localize this region for RNA secondary structures subject to various base pairing rules and minimum arc- and stack-length restrictions. In particular, for GC-sequences having a ratio of G nucleotides smaller than 1/3, a random RNA secondary structure without any minimum arc- and stack-length restrictions has a.a.s. no such compatible sequence. For sequences having a ratio of G nucleotides larger than 1/3, a random RNA secondary structure has a.a.s. such compatible sequences. We discuss our results in the context of various families of RNA structures.
arXiv:1603.03653v1 fatcat:rqkxkruicjefjpcxsflyg5cflu