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Optimal Treatment Strategies for HIV with Antibody Response
2014
Journal of Applied Mathematics
Numerical analysis and optimization tools are used to suggest improved therapies to try and cure HIV infection. An HIV model of ordinary differential equation, which includes immune response, neutralizing antibodies, and multidrug effects, is improved. For a fixed time, single-drug and two-drug treatment strategies are explored based on Pontryagin's maximum principle. Using different combinations of weight factor pairs combining with special upper-bound pairs for controls, nine types of
doi:10.1155/2014/685289
fatcat:2biaj6qn5bdyzdhkldtlfpw2ei