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Antibody responses are triggered when a B cell extracts and internalises antigen from an antigen-presenting cell. The sensitivity with which B cells detect antigen, and the quality and quantity of antigen that B cells acquire, depend upon mechanical properties of the immune synapse including interfacial tension, the strength of intermolecular bonds, and the compliance of the molecules and membranes that participate in antigen presentation. In this review, we discuss our current understanding ofdoi:10.1007/978-1-4939-7474-0_5 pmid:29388100 fatcat:nwd3xpbo6vfxxbehgru7dldh64