DNA-Based Probes for Measuring Mechanical Forces in Cell-Cell Contacts: Application to B Cell Antigen Extraction from Immune Synapses [chapter]

Katelyn M. Spillane, Pavel Tolar
2018 Msphere  
Antibody responses are triggered when a B cell extracts and internalises antigen from an antigen-presenting cell. The sensitivity with which B cells detect antigen, and the quality and quantity of antigen that B cells acquire, depend upon mechanical properties of the immune synapse including interfacial tension, the strength of intermolecular bonds, and the compliance of the molecules and membranes that participate in antigen presentation. In this review, we discuss our current understanding of
more » ... nt understanding of how these various physical parameters influence B cell antigen extraction in the immune synapse and how a more comprehensive understanding of B cell mechanics may promote the development of new approaches to stimulate the production of desired antibodies.
doi:10.1007/978-1-4939-7474-0_5 pmid:29388100 fatcat:nwd3xpbo6vfxxbehgru7dldh64