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Regular Long-Term Continuous Replacement Therapy for Hemophilia
The Japanese Journal of Pediatric Hematology
Hemophilia treatment in Japan is mainly on-demand therapy in which a deficient coagulation factor VIII or IX concentrate is administered to stop bleeding when it occurs. Although home infusion therapy on demand has improved QOL in hemophiliacs in Japan, progressive musculoskeletal damage such as hemophilic arthropathy still remains a problem due to frequent hemarthroses. In recent years, prophylactic therapy in which a deficient coagulation factor is regularly administered for a long period todoi:10.11412/jjph1987.19.67 fatcat:b4vzwrhvfjbwzpdlvqmt7pgjvu