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A novel canine reference genome resolves genomic architecture and uncovers transcript complexity
2021
Communications Biology
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AbstractWe present GSD_1.0, a high-quality domestic dog reference genome with chromosome length scaffolds and contiguity increased 55-fold over CanFam3.1. Annotation with generated and existing long and short read RNA-seq, miRNA-seq and ATAC-seq, revealed that 32.1% of lifted over CanFam3.1 gaps harboured previously hidden functional elements, including promoters, genes and miRNAs in GSD_1.0. A catalogue of canine "dark" regions was made to facilitate mapping rescue. Alignment in these regions
doi:10.1038/s42003-021-01698-x
pmid:33568770
fatcat:sme5phtnubgkzgwqrfooa6ncn4