Epidemiological and TNFα polymorphism evaluation in patients with cryptococcal meningitis treated at a referral hospital in North Brazil

Alena Mileo Monteiro Diniz, Danielle Cristinne Azevedo Feio, Aniel de Sarom Negrão Silva, Rommel Rodríguez Burbano, Patrícia Danielle Lima de Lima
2019 Revista da Sociedade Brasileira de Medicina Tropical  
The present study evaluated the epidemiology of cryptococcal meningitis and TNFα gene polymorphisms in patients at a reference hospital in northern Brazil. Methods: Samples from 25 patients infected with Cryptococcus spp. were collected to confirm the infection and to analyze the TNFα gene polymorphisms. Results: Cryptococcus neoformans was detected as the predominant etiological agent (100%) in HIV-positive patients. No genetic polymorphic changes were found. Conclusions: No correlation was
more » ... correlation was observed between the analyzed TNFα polymorphisms and cryptococcal meningitis.
doi:10.1590/0037-8682-0376-2018 fatcat:l4yui5w3p5fjzb3o5gbyl2uvtu