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This paper presents a semantic-mediation architecture that enables standards-based interoperability between heterogeneous supply-chain applications. The architecture was implemented using a state-of-the-art semantic-mediation toolset for design-time and run-time integration tasks. The design-time tools supported a domain ontology definition, message annotations, message schema transformations, and reconciliation rules specifications. The run-time tools performed exchanges, transformations, anddoi:10.1080/09511920802616781 fatcat:s6gm7kz36vdnddtau4ni72b5xi