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Regulation of fibronectin gene expression by cyclic AMP and phorbol myristate acetate in HT-1080 human fibrosarcoma cells
Experimental and Molecular Medicine
We studied the regulation of fibronectin (FN) gene expression by cAMP and phorbol-12-myristate-13acetate (PMA) in HT-1080 human fibrosarcoma cells. Dibutyryl cAMP increased FN synthesis and mRNA levels, while PMA inhibited the cAMP-induced FN synthesis. In transient transfection assays, cAMP increased FN promoter activity, while PMA paradoxically enhanced the cAMP-induced promoter activity. Stable transfection experiments, however, showed that neither cAMP or PMA alone nor together affected FNdoi:10.1038/emm.1998.35 pmid:9894155 fatcat:bbp7eazwzbdz3d5javhsptivzm