Clinical manifestations, treatment, and outcomes of children and adolescents with eosinophilic esophagitis

Maraci Rodrigues, Maria Fernanda M. D'Amico, Fatima Regina Almeida Patiño, Dorina Barbieri, Aderson Omar Mourão Cintra Damião, Aytan M. Sipahi
2013 Jornal de Pediatria  
Objective: This study aimed to describe the clinical, endoscopic, and histologic characteristics, as well as the response to conventional treatment of pediatric patients with the classical form of eosinophilic esophagitis (EoE). Methods: Study of clinical, laboratory, endoscopic, and histologic data and response to conventional treatment of 43 previously followed pediatric patients with the classical form of EoE. Results: A total of 43 patients diagnosed with EoE were included in the study, of
more » ... hich 37 were males (86%), with a mean age of 8.4 years. The most common symptoms were: nausea, vomiting, and abdominal pain (100%) in children younger than 7 years, and loss of appetite (60%), heartburn (52%), and food impaction (48%) in children older than 7 years and adolescents. Regarding the endoscopic findings, 12 (28%) patients had whitish plaques on the esophageal lining, 8 (18.5%) had longitudinal grooves, 2 (4.5%) had concentric rings, 3 (7%) had longitudinal grooves and whitish plaques, and the remaining 18 (42%) had esophageal mucosa with normal appearance. Despite the initial favorable response, 76.7% of patients required more than one course of corticosteroid
doi:10.1016/j.jped.2013.03.001 pmid:23642431 fatcat:rzqj7rajizaddbm42ststip55y