The 128-Channel Fully Differential Digital Integrated Neural Recording and Stimulation Interface

Farzaneh Shahrokhi, Karim Abdelhalim, Demitre Serletis, Peter L. Carlen, Roman Genov
2010 IEEE Transactions on Biomedical Circuits and Systems  
We present a fully differential 128-channel integrated neural interface. It consists of an array of 8 16 low-power low-noise signal-recording and generation circuits for electrical neural activity monitoring and stimulation, respectively. The recording channel has two stages of signal amplification and conditioning with and a fully differential 8-b column-parallel successive approximation (SAR) analog-to-digital converter (ADC). The total measured power consumption of each recording channel,
more » ... luding the SAR ADC, is 15.5 W. The measured input-referred noise is 6.08 V rms over a 5-kHz bandwidth, resulting in a noise efficiency factor of 5.6. The stimulation channel performs monophasic or biphasic voltage-mode stimulation, with a maximum stimulation current of 5 mA and a quiescent power dissipation of 51.5 W. The design is implemented in 0.35-m complementary metal-oxide semiconductor technology with the channel pitch of 200 m for a total die size of 3.4 mm 2.5 mm and a total power consumption of 9.33 mW. The neural interface was validated in in vitro recording of a low-Mg 2+ /high-K + epileptic seizure model in an intact hippocampus of a mouse. Index Terms-Brain, extracellular recording, hippocampus, implantable, multichannel neural recording, multichannel neural stimulation, neural amplifier, SAR analog-to-digital converter (ADC).
doi:10.1109/tbcas.2010.2041350 pmid:23853339 fatcat:h4fophb4nfgohdrhynccqpdyuq