New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation

Anna Carbone, Barbara Parrino, Maria Cusimano, Virginia Spanò, Alessandra Montalbano, Paola Barraja, Domenico Schillaci, Girolamo Cirrincione, Patrizia Diana, Stella Cascioferro
2018 Marine Drugs  
New thiazole nortopsentin analogues were conveniently synthesized and evaluated for their activity as inhibitors of biofilm formation of relevant Gram-positive and Gram-negative pathogens. All compounds were able to interfere with the first step of biofilm formation in a dose-dependent manner, showing a selectivity against the staphylococcal strains. The most active derivatives elicited IC50 values against Staphylococcus aureus ATCC 25923, ranging from 0.40–2.03 µM. The new compounds showed a
more » ... pical anti-virulence profile, being able to inhibit the biofilm formation without affecting the microbial growth in the planktonic form.
doi:10.3390/md16080274 pmid:30081568 fatcat:uwo6npq3ufej5mhwbxzidvee3e