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New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation
2018
Marine Drugs
Preserved Fulltext
New thiazole nortopsentin analogues were conveniently synthesized and evaluated for their activity as inhibitors of biofilm formation of relevant Gram-positive and Gram-negative pathogens. All compounds were able to interfere with the first step of biofilm formation in a dose-dependent manner, showing a selectivity against the staphylococcal strains. The most active derivatives elicited IC50 values against Staphylococcus aureus ATCC 25923, ranging from 0.40–2.03 µM. The new compounds showed a
doi:10.3390/md16080274
pmid:30081568
fatcat:uwo6npq3ufej5mhwbxzidvee3e