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New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation
New thiazole nortopsentin analogues were conveniently synthesized and evaluated for their activity as inhibitors of biofilm formation of relevant Gram-positive and Gram-negative pathogens. All compounds were able to interfere with the first step of biofilm formation in a dose-dependent manner, showing a selectivity against the staphylococcal strains. The most active derivatives elicited IC50 values against Staphylococcus aureus ATCC 25923, ranging from 0.40–2.03 µM. The new compounds showed adoi:10.3390/md16080274 pmid:30081568 fatcat:uwo6npq3ufej5mhwbxzidvee3e