Disrupted development and imbalanced function in the global neuronal workspace: a positive-feedback mechanism for the emergence of ASD in early infancy

Chris Fields, James F. Glazebrook
2016 Cognitive Neurodynamics  
Autism spectrum disorder (ASD) is increasingly being conceptualized as a spectrum disorder of connectome development. We review evidence suggesting that ASD is characterized by a positive feedback loop that amplifies small functional variations in early-developing sensoryprocessing pathways into structural and functional imbalances in the global neuronal workspace. Using vision as an example, we discuss how early functional variants in visual processing may be feedback-amplified to produce
more » ... nt object categories and disrupted top-down expectations, atypically large expectation-to-perception mismatches, problems re-identifying individual people and objects, socially inappropriate, generally aversive emotional responses and disrupted sensory-motor coordination. Viewing ASD in terms of feedback amplification of small functional variants allows a number of recent models of ASD to be integrated with neuroanatomical, neurofunctional and genetic data.
doi:10.1007/s11571-016-9419-8 pmid:28174609 pmcid:PMC5264757 fatcat:6emdbdl7urh3tig4k6wjirlzqa