Cancer preventive Effect of Morinda citrifolia (Noni) fruit juice against the AflatoxinB1-induced genotoxicity in human peripheral lymphocytes in vitro

2012 IOSR Journal of Pharmacy (IOSRPHR)  
Morinda citrifolia (Noni) has been used in folk medicine by Polynesians for over 2,000 years and is reported to have a broad range of therapeutic effects, including anticancer activity. The exact mechanism of action is unknown. The hypothesis is generated from the experiment that Morinda citrifolia possesses a cancer preventive effect at the initiative stage of carcinogenesis. The antigenotoxic potential of Noni juice (NJ) was demonstrated on the aflatoxin B1 induced genotoxicity. In vitro
more » ... city. In vitro studies were carried on human lymphocyte culture. We have used chromosomal aberration (CA), sister chromatid exchange (SCE) and cell cycle kinetics (CCK) with and without S 9 mix. as markers in this experiments. Four doses viz., 200, 250, 300, 350 µl/ml per culture were selected and found that NJ significantly reduces the frequencies of chromosomal aberration, sister chromatid exchanges and enhances RI in vitro .It was also noticed that the antigenotoxic potential of NJ shows doseresponse relationship. The results suggest that NJ was a potent anticarcinogen may contribute to the cancer prevention.
doi:10.9790/3013-0220228234 fatcat:3s7k4amur5f6nfeausw54kkz4e