Anti-beta 2-glycoprotein I antibodies: a useful marker for the antiphospholipid syndrome

M. Teixido, J. Font, J. C. Reverter, R. Cervera, D. Tassies, M. Ingelmo, G. Escolar, A. Ordinas
1997 Rheumatology  
We studied anti-b2-glycoprotein I antibodies (ab2GPI) in autoimmune disease patients to evaluate their relationship to clinical findings. Seventy-nine systemic lupus erythematosus (SLE) patients [44 with antiphospholipid antibodies (aPL)], 21 with primary antiphospholipid syndrome (APS), eight asymptomatic individuals with aPL and 60 controls were studied. Sixteen SLE patients (14 with aPL and two without aPL) and six with primary APS had ab2GPI. A significant relationship was found between
more » ... s found between ab2GPI and aPL (P Q 0.01). In SLE, a significant correlation was found between previous thrombosis or thrombocytopenia and ab2GPI or ab2GPI + aPL, but not between fetal losses and ab2GPI. These data suggest that ab2GPI may be useful in the study of APS.
doi:10.1093/rheumatology/36.1.113 pmid:9117149 fatcat:xvpv472xrvbnnhytps6kovvtmy