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Analysis of Polygenic Score Usage and Performance across Diverse Human Populations
Studies of the relationship between genetic and phenotypic variation have historically been carried out on people of European ancestry. Efforts are underway to address this limitation, but until they succeed, the legacy of a Euro-centric bias in medical genetic studies will continue to hinder research, including the use of polygenic scores, which are individual-level metrics of genetic risk. Ongoing debate surrounds the generalizability of polygenic scores based on genome-wide associationdoi:10.1101/398396 fatcat:ylgn6fzegrfnhnmxed22vge23i