Targeting DNA Repair Pathways in Hematological Malignancies

Jehad F. Alhmoud, Ayman G. Mustafa, Mohammed Imad Malki
2020 International Journal of Molecular Sciences  
DNA repair plays an essential role in protecting cells that are repeatedly exposed to endogenous or exogenous insults that can induce varying degrees of DNA damage. Any defect in DNA repair mechanisms results in multiple genomic changes that ultimately may result in mutation, tumor growth, and/or cell apoptosis. Furthermore, impaired repair mechanisms can also lead to genomic instability, which can initiate tumorigenesis and development of hematological malignancy. This review discusses recent
more » ... w discusses recent findings and highlights the importance of DNA repair components and the impact of their aberrations on hematological malignancies.
doi:10.3390/ijms21197365 pmid:33036137 fatcat:k3pfkrohvfgb5m2lpaz2ajueiu