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Targeting DNA Repair Pathways in Hematological Malignancies
2020
International Journal of Molecular Sciences
DNA repair plays an essential role in protecting cells that are repeatedly exposed to endogenous or exogenous insults that can induce varying degrees of DNA damage. Any defect in DNA repair mechanisms results in multiple genomic changes that ultimately may result in mutation, tumor growth, and/or cell apoptosis. Furthermore, impaired repair mechanisms can also lead to genomic instability, which can initiate tumorigenesis and development of hematological malignancy. This review discusses recent
doi:10.3390/ijms21197365
pmid:33036137
fatcat:k3pfkrohvfgb5m2lpaz2ajueiu