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Thiol-Reactive Analogues of Galanthamine, Codeine, and Morphine as Potential Probes to Interrogate Allosteric Binding within Nicotinic Acetylcholine Receptors
2015
Australian journal of chemistry (Print)
16 Alkaloids including galanthamine (1) and codeine (2) are reported to be positive allosteric 17 modulators of nicotinic acetylcholine receptors (nAChRs) but the binding sites responsible 18 for this activity are not known with certainty. Analogues of galanthamine (1), codeine (2) and 19 morphine (3) with reactivity towards cysteine thiols were synthesised including conjugated 20 enone derivatives of the three alkaloids 4-6 and two chloro-alkane derivatives of codeine 7 21 and 8. The stability
doi:10.1071/ch15475
fatcat:4pttwv2njfhozi2zflctta7ki4