Small Size Nanosilver Multi Organ Toxicity: A Higher Dose Negative Response in In-Vivo and In-Vitro Experimental Application

Jyoti Prakash Pani
2017 Biomedical Journal of Scientific & Technical Research  
Multi organ toxicity of nanosilver depends on shape and injected dose of the particle concerned. But rate of toxicity is based on mode of tissue permeability predominant in repeated oral route application. Spiny and tiny nanosilver of small size colloid cool watery solution is being extensively and serially utilized in critical but human beneficiary scientific experiment. In this existing study, we evaluated the multi organ toxic effects of various small sizes silver nanoparticles of 2.45 to
more » ... 53 nanometer size range in pregnant Swiss Albino mouse freshly dissected internal vital abdominal viscera tissues, with different doses such as 0.37, 0.65, 13 and 21 mg/kg body weight on kidney, liver and spleen tissues via oral gavages for 27 days followed by in-vivo and in-vitro application. Destructive responses on above mentioned multi abdominal viscera's were observed in high 13 and 21 mg/kg dose small size AgNps treated group, when visualized by routine histology mode. Histological and gross examination showed tissue destruction, blood tinged focuses, cell necrosis and programmed cell death dilemma from all mouse in high dose group compared to control group. But lower dose group executed negotiable effect almost equal to control. Depend on these types of hazardous features, it is postulated that the effect of small size nanosilver particles on the exposed tissues may cause multi organ vital viscera's toxicity in mice.
doi:10.26717/bjstr.2017.01.000360 fatcat:hzhnzxtoajextatt3gwxkaf7ly