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Clonality inference in multiple tumor samples using phylogeny
2015
Computer applications in the biosciences : CABIOS
Intra-tumor heterogeneity presents itself through the evolution of subclones during cancer progression. While recent research suggests that this clonal diversity is a key factor in therapeutic failure, the determination of subclonal architecture of human tumors remains a challenge. To address the problem of accurately determining subclonal frequencies in tumors as well as their evolutionary history, we have developed a novel combinatorial method named CITUP (Clonality Inference in Tumors Using
doi:10.1093/bioinformatics/btv003
pmid:25568283
fatcat:35rpbac3ibeajeph6diznre2du