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Insights gained from a comprehensive all-against-all transcription factor binding motif benchmarking study
2020
Genome Biology
Positional weight matrix (PWM) is a de facto standard model to describe transcription factor (TF) DNA binding specificities. PWMs inferred from in vivo or in vitro data are stored in many databases and used in a plethora of biological applications. This calls for comprehensive benchmarking of public PWM models with large experimental reference sets. Here we report results from all-against-all benchmarking of PWM models for DNA binding sites of human TFs on a large compilation of in vitro
doi:10.1186/s13059-020-01996-3
pmid:32393327
fatcat:paqghcw6jrazbizkn5itbf4rly