Poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) nanofibers coated with micro-patterned diamond-like carbon (DLC) for the controlled drug release

Kenta Bito, Tomoki Maeda, Katsuya Hagiwara, Soki Yoshida, Terumitsu Hasebe, Atsushi Hotta
2015 Journal of Biorheology  
Attaining high hemocompatibility and promoting endothelialization are two major keys to solve the endoleak problems observed in existing stent-grafts. For the satisfactory long-term use of the stent-grafts, blocking the endoleak symptom is highly essential. This paper deals with the fabricationofelectrospunnanofibersmadeofantithrombogenic poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) containing drug that can sustain the endothelial activityoftheMPCnanofibers.Moreover,thedrugrelease was
more » ... hedrugrelease was controlled by micro-patterned diamond-like carbon (DLC) coated on the MPC nanofibers. It was found that MPC nanofibersretained excellenthemocompatibilityand that the micro-patterned DLC efficiently controlled the drug-releaserateofMPCfibers.
doi:10.17106/jbr.29.51 fatcat:jriajcslbbgvvg3xzjqb4mfhdi