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Heme Oxygenase-1-Mediated Protection: Potential Role of Nonheme Iron-Nitric Oxide Complexes * Response
2002
Circulation
In a recent paper, Tulis and coworkers 1 reported that transfectional overexpression of heme oxygenase-1 (HO-1) inhibits arterial remodeling after balloon angioplasty via a mechanism involving apoptosis. HO-1 is a stress response protein that degrades heme to carbon monoxide, biliverdin, and nonheme iron. In general, overexpression of HO-1 plays a cytoprotective role against a variety of oxidative stimuli. Interestingly, cells overexpressing HO-1 exhibit low levels of free iron because of the
doi:10.1161/01.cir.0000018903.08414.ff
pmid:12082007
fatcat:itsdm2uluzbkxhevqcphfr4orq