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Regulation of chromatin structure in memory formation
2009
Current Opinion in Neurobiology
This brief review focuses on the role of epigenetic mechanisms in plasticity and memory formation, and their identification as targets of activity-dependent regulation in neurons. Epigenetic modifications of chromatin, namely post-translational modifications of nuclear proteins and covalent modification of DNA, result in potent regulation of gene readout. Recent data have demonstrated that epigenetic mechanisms play a significant role in regulating synaptic plasticity and memory. In this
doi:10.1016/j.conb.2009.05.011
pmid:19539459
pmcid:PMC2744442
fatcat:6adfwot5abdwzemmzxdlklon7m